I found a ‘small’ glitch in Mass Effect the other day while playing the Noveria mission. There’s a point where you have to go to the Peak 15 facility to track down Matriarch Benezia, but I discovered that, if you do things out of order there — like breaking into the secure lab through the front door, having to shoot all the guards in the place, and then blowing the neutron charge before making the cure — all the NPCs in Peak 15 disappear and you can’t complete the mission. Good thing I’m paranoid about having multiple — and frequent — save points.

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